Gabapentin for acute and chronic pain

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Gabapentin for acute and chronic post-surgical pain

Pain after surgery remains a significant clinical problem as it impairs recovery adversely and may lead to the transition to chronic pain. Opioid medications are far from ideal agents in suppressing postoperative pain. Gabapentin –an anticonvulsant with antihyperalgesic propertiesoriginally efficacious against neuropathic pain seems to be very promising for the management of pain after surgery ...

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Gabapentin for Chronic Neuropathic Pain.

Narrative: Neuropathic pain, when the pain generator is the nerve itself, occurs in a variety of conditions including diabetes mellitus and postherpetic neuropathy. The exact mechanism of action for these conditions is unclear. Some speculate that aberrant nerve signal modulation may be a culprit, which would explain why neuropathic pain rarely responds adequately to traditional analgesics, and...

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Gabapentin for Acute Postoperative Pain

EVIDENCE DEFINITIONS  Class I: Prospective randomized controlled trial.  Class II: Prospective clinical study or retrospective analysis of reliable data. Includes observational, cohort, prevalence, or case control studies.  Class III: Retrospective study. Includes database or registry reviews, large series of case reports, expert opinion.  Technology assessment: A technology study which doe...

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Gabapentin in Acute Postoperative Pain Management

Gabapentin (1-aminomethyl-cyclohexaneacetic acid) is an amino acid that has the structure of the neurotransmitter γ -aminobutyric acid (GABA). It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a unique mechanism of action. Gabapentin and the related, more potent compound pregabalin have been shown to be beneficial in the treatment of neuropathi...

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ژورنال

عنوان ژورنال: Cochrane Database of Systematic Reviews

سال: 2011

ISSN: 1465-1858

DOI: 10.1002/14651858.cd005452.pub2